The Associated Press reported that a cloud of smoke was rising from Tehran’s downtown area. The apparent strike happened near the offices of Supreme Leader Ayatollah Ali Khamenei, according to the AP report.

Trump said that Iran had “attempted to rebuild their nuclear program and to continue developing long-range missiles that can now threaten our very good friends and allies in Europe, our troops stationed overseas and could soon reach the American homeland.”

Israeli Defense Minister Israel Katz announced that Israel had launched a “preemptive” strike against Iran early Saturday.

The Israeli government declared a state of alert across the country because of the expectation of Iranian retaliation. “This is a proactive alert to prepare the public for the possibility of missiles being launched toward the State of Israel,” the Israel Defense Forces (IDF) said in a post on X.

The IDF later said it had “identified missiles launched from Iran toward Israel.”

Trump has threatened to take action for months, and amassed the largest military buildup in the region since the 2003 U.S. invasion of Iraq. He initially argued the U.S. would intervene to assist anti-government protesters, thousands of whom were killed in January. But as protests waned and nuclear talks between the U.S. and Iran renewed in February, Trump began threatening to use force if Tehran didn’t agree to curb its nuclear program.

The strikes early Saturday mark the latest military intervention in Trump’s increasingly muscular foreign policy, and come after U.S. special forces captured Venezuelan President Nicolás Maduro in January. They also underscore the president’s willingness to take major military gambles abroad, even at the risk of escalating feuds with foes and destabilizing alliances.

But the Trump administration has said little publicly about what it would do to avoid civil unrest if the strikes manage to destabilize a regime that has prevailed for nearly half a century.

In late January, Trump said he would attack Iran with “speed and violence” if leaders did not agree to U.S. demands, referencing his desire for Tehran to permanently end its enrichment of uranium. Trump, in his State of the Union address in February, accused Iran of restarting its nuclear weapons program — a claim Iran has denied.

Israeli Prime Minister Benjamin Netanyahu, who Trump and top administration officials met with throughout the negotiating process, has also encouraged the U.S. to demand Tehran curb its ballistic missile program and halt funding for its proxy groups in the region. Israel has urged strong military action, pushing for strikes that would target, not only Iranian centrifuges, but also Islamic Revolutionary Guard Corps command-and-control nodes.

Netanyahu hailed the U.S.-Israeli attack Saturday morning. “A short time ago, Israel and the United States embarked on an operation to remove the existential threat posed by the terrorist regime in Iran,” he said in a post on X.

“Our joint action will create the conditions for the courageous Iranian people to take their destiny into their own hands,” he said.